3 articles tagged “reverse-t3”.
If you have Hashimoto's, take levothyroxine, and your labs are "perfect" but you still feel awful, there is a mechanism for that. Levothyroxine is pure T4, and T4 has to be converted to active T3 to do anything. When that conversion fails, more T4 does not fix it.
If you have ME/CFS and every hypothyroid symptom but "normal" thyroid labs, the problem may be tissue-level, not in your blood. Here is how reverse T3, the DIO2 enzyme, and selenoprotein P autoantibodies hide cellular hypothyroidism from a standard panel.
Your TSH is fine. Your T4 is fine. You are freezing cold, exhausted, foggy, and your doctor says your thyroid is "perfect." You are not imagining this. The deficiency is real, it is just happening inside your cells where the blood test cannot reach.